G蛋白相關(guān)RABX5抗體
規(guī)格：1mg/1ml
英文名： RABX5
別名： Rabex5; RAB guanine nucleotide exchange factor (GEF) 1; Rab5 GDP/GTP exchange factor; Rab5ef; Rabaptin 5 associated exchange factor for Rab5; Rabaptin-5-associated exchange factor for Rab5; Rabex 5; R
分子量： 79kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RABX5
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
細(xì)胞定位：細(xì)胞漿
G蛋白相關(guān)RABX5抗體產(chǎn)品介紹：background: RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010] Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). Subunit: Interacts with RGS14; the interaction is GTP-dependent (By similarity)G蛋白相關(guān)RABX5抗體. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR Subcellular Location: Cytoplasm. Early endosome. Recycling endosome. Post-translational modifications: Monoubiquitinated.G蛋白相關(guān)RABX5抗體 Similarity: Contains 1 A20-type zinc finger. Contains 1 VPS9 domain. Database links: Entrez Gene: 27342 Human Entrez Gene: 56715 Mouse Entrez Gene: 360797 Rat Omim: 609700 Human SwissProt: Q9UJ41 Human SwissProt: Q9JM13 Mouse Unigene: 530053 Human Unigene: 288639 Mouse Unigene: 21688 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白相關(guān)RABX5抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 G蛋白偶聯(lián)受體 G蛋白信號(hào)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid