黑色素瘤相關(guān)抗原C2抗體
規(guī)格：1mg/1ml
英文名： MAGEC2
別名： Cancer testis antigen 10; Cancer/testis antigen 10; CT10; HCA587; Hepatocellular carcinoma associated antigen 587; Hepatocellular carcinoma-associated antigen 587; MAGC2_HUMAN; MAGE C2 antigen; MAGE E
分子量： 41kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAGEE1/M
交叉反應(yīng)：Human, Mouse, Rat, Pig, Cow,
細(xì)胞定位：細(xì)胞核 細(xì)胞漿
黑色素瘤相關(guān)抗原C2抗體產(chǎn)品介紹：background: Tissue specificity; Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. Subunit: Interacts with TRIM28 and UBE2H. Subcellular黑色素瘤相關(guān)抗原C2抗體 Location: Cytoplasm. Nucleus. Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma. Tissue Specificity: Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a黑色素瘤相關(guān)抗原C2抗體 inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. Similarity: Contains 1 MAGE domain. Database links: UniProtKB/Swiss-Prot: Q9UBF1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品應(yīng)用：黑色素瘤相關(guān)抗原C2抗體WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 **學(xué) 腫瘤細(xì)胞生物標(biāo)志物
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid